Question: Mouse RNA-seq research
gravatar for sugus
7 months ago by
China Pharmaceutical University
sugus40 wrote:

Hi there,

I have some mouse rna-seq data and would like to do some functional enrichment analysis, but I do not have such robust signatures designed just for mouse, such as MSigDB.

Thus, I wonder is it logical to convert mouse gene to human gene, and perform the typical downstream analysis just like I am dealing with a human RNA-Seq data.

And if this is not right at all, is there any pathways (signature) database designed exactly for mouse-related research?

Many thanks advanced.

human rna-seq mouse • 210 views
ADD COMMENTlink written 7 months ago by sugus40

MSigDB gene sets are not just for human. They are just converted to human symbols for consistency. The gene sets come from different species and there is actually an organism specified for each. For example: ABBUD_LIF_SIGNALING_2_DN is based on Rattus norvegicus.

ADD REPLYlink written 7 months ago by igor9.6k
gravatar for mmfansler
7 months ago by
MSKCC | New York, NY
mmfansler350 wrote:

Perhaps have a look at MouseMine:

ADD COMMENTlink written 7 months ago by mmfansler350
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