Question: Detecting Dispersed vs tandem duplicated
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gravatar for znl207
11 months ago by
znl20710
znl20710 wrote:

I am working with CNVs in a population, I've used a couple of different detection methods, I am currently using lumpy and delly- I am wondering if folks have any recommendations for distinguishing between dispersed and tandem duplications from the output of various CNV/SV detection tools. How would you go about detecting if a duplication is tandem vs. dispersed? Thanks!

delly lumpy cnv tools sv • 247 views
ADD COMMENTlink modified 4 months ago by piechota.marcin70 • written 11 months ago by znl20710
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gravatar for piechota.marcin
4 months ago by
European Union
piechota.marcin70 wrote:

For tandem duplication you will find reverse order pairs around breaking points. Left read just before ending breaking point and right read just after starting breaking point. For dispersed duplication you will find larger than expected insert size for read pairs around breaking points. One read within borders of CNV and second read outside borders of CNV (pairs can be reverse or in order).

ADD COMMENTlink written 4 months ago by piechota.marcin70
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