Off topic:what is the relation between protein domains and diseases ?

Question

[ahmedmelmoselhy]

I am computer science student, and I want to work in bioinformatics. I am just at the beginning of learning some biology concepts. I am asking about the relation between protein domains and diseases, does it exists ? if so, what is the type of this relation ? In another word, can we say that a domain X is related/associated with disease Y. I am saying that because I read somewhere that there is a kind of drug design techniques called target based drug design, which can be helpful if ,for example, we knew that a domain is associated to a certain domain, this can help in targeting that domain as a drug target to produce a drug for that disease.