None of your groups has replicates ? If not it will be very difficult (even impossible) to have reliable results ..
Nevertheless in the DESeq2 vignette : https://bioconductor.org/packages/release/bioc/vignettes/DESeq2/inst/doc/DESeq2.html#can-i-use-deseq2-to-analyze-a-dataset-without-replicates
I'm afraid the only valid answer here will be NOT .
if you insist have a look here: http://bioconductor.org/packages/devel/bioc/vignettes/DESeq2/inst/doc/DESeq2.html (first hit on google btw)