RNA-seq differential analysis: quasi-likelihood F-test versus likelihood ratio test

Question

[Adeler001]

Hello I'm trying to do a rna seq differential analysis. I've been trying to search the web for what the difference is between quasi-likelihood F-test and the likelihood ratio test but still dont understand the difference , can someone please explain what difference is between the two tests? and which test is better when you doing rna seq differential analysis with unpaired samples ?

[ATpoint]

Have you read this from Aaron Lun? https://support.bioconductor.org/p/68629/