in silico engineering of NGS files

Question

[mendel.roth]

Does anyone know how to engineer a FASTQ, SAM or BAM or related NGS data file so to test a bioinformatics pipeline for novel copy number variation calling? I am hoping to tweak sequence data to simulate CNV NGS data and run those files through several pipelines for validation studies. Thank you

[GenoMax]

See this prior thread for some resources: Gold standard CNV Calls for NA12878

There is: http://dgv.tcag.ca/dgv/app/home

These are real samples. Not engineered ones.

[WouterDeCoster]

I would suggest googling for "simulating fastq" files, or similar terms.