Question: gene transcription direction
gravatar for 9521ljh
10 months ago by
9521ljh20 wrote:

gene: PTPRR

Above website, I notice the PTPRR gene transcription direction is 3'->5' because Transcript Strand is -, and Trasncript position: hg19 chr12:71,031,853-71,314,584

However, SLC2A13 gene, this show Transcript strand is - , but Transcript position is hg19 chr12:40,148,823-40,499,661 (5'->3' ???)

Therefore, to identify the direction of transcription, what should I look for?

sequencing gene genome • 318 views
ADD COMMENTlink modified 10 months ago by RamRS28k • written 10 months ago by 9521ljh20
gravatar for WouterDeCoster
10 months ago by
WouterDeCoster44k wrote:

genomic coordinates are always

chromosome:smallest-largest I don't understand how you conclude about 5' and 3' in your question.

Note that RNA is always 5'-3', but sometimes the RNA 5' can have a higher genomic coordinate than the RNA 3', meaning it is transcribed from the negative strand. Don't confuse the strand of the mRNA with the direction on the chromosome.

ADD COMMENTlink written 10 months ago by WouterDeCoster44k

thank you so much!!, i miss some point of concept of transcription before.

ADD REPLYlink modified 10 months ago • written 10 months ago by 9521ljh20
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