Question: Meta-analysis on microaray data, when a sinlge experiment contains diferent tissues
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gravatar for catechize.2.learn
4 weeks ago by
catechize.2.learn110 wrote:

Hi!

I dont know whether this is the best place to ask this question, however:

Suppose I want to perform meta-analysis on 10 different microarray studies.

Study      Tissue/source
Study1     Neuron
Study2     Blood
Study3     Neuron and PBMC
......     .....
Study10    ...

How should I treat Study3?

The R package I want to use is among MetaMA or MetaDE, and perhaps crossMeta

Even a reference article/book/tutorial would be appreciated.

Thanks in advance

microarray meta-analysis • 443 views
ADD COMMENTlink modified 4 weeks ago by Kevin Blighe50k • written 4 weeks ago by catechize.2.learn110
1
gravatar for Kevin Blighe
4 weeks ago by
Kevin Blighe50k
Kevin Blighe50k wrote:

The transcriptional profiles of neurons and PBMCs are 'quite' (very) different, so, you may consider dividing that study into two separate studies and regarding them as Study3a and Study3b.

Kevin

ADD COMMENTlink written 4 weeks ago by Kevin Blighe50k

Thank you indeed very much. Is there a quantitative measure in common use for such situations? Another question as you are a moderator of biostars, why there is no upvote or accept buttons (for your post/for my profile) so that I can thank in that way and others benefit from the post?

ADD REPLYlink written 4 weeks ago by catechize.2.learn110
1

Voting buttons are not per profile. You will find them on comments/answers in threads. They are present at top left of post.

If you are not able to see the buttons try a different browser or make sure scripting is allowed for biostars.org.

Upvote|Bookmark|Accept

ADD REPLYlink modified 4 weeks ago • written 4 weeks ago by genomax73k

Thanks genomax. I used to see and use the buttons and that is why I apologized. I tried Firefox 69 and Palemoon 27 (my default browser which used to show the stuff) neither showing the buttons for answers but showing upvote button for comments.

ADD REPLYlink written 4 weeks ago by catechize.2.learn110

I am not sure if Chrome browser is available in your locale. You should give that a try.

ADD REPLYlink modified 4 weeks ago • written 4 weeks ago by genomax73k
2

Jut installed chrome and the functionality was restored in my original browser (palemoon).

ADD REPLYlink written 4 weeks ago by catechize.2.learn110

Chrome is available to me but makes my laptop sluggish. FYI I also used Slimjet (also based on blink) on win 7 and Chrome and opera mini beta (the latter two on android) with no success.

ADD REPLYlink written 4 weeks ago by catechize.2.learn110

I wonder could you provide a screenshot of what you are seeing? You can upload an image here, and then just paste the complete URL in the conversation window on this website: https://imgbb.com/

ADD REPLYlink modified 4 weeks ago • written 4 weeks ago by Kevin Blighe50k
1

enter image description here OS= Win 7

update:

Jut installed chrome and the functionality was restored in my original browser (palemoon).

ADD REPLYlink modified 4 weeks ago • written 4 weeks ago by catechize.2.learn110
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