Hello, We are trying to analyze a set of single cell data sets from different sources but we have a problem. One of the data set is in TPM and another one is in FPKM format. It is easy to do batch correction with raw counts (with CCA in Seurat or MNN in Scater) but we have no idea how to deal with this problem.
Do you think we can use TPM and FPKM values for batch correction since they are already normalized. Another option is to convert values to raw counts but we have no idea how to do it.
Thank you in advance.