In Foundation Medicine's Tumor Mutation Burden (TMB) study... https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0424-2
They claim a median of 3.6 somatic mutations per Mb (million) in metasticised samples. Despite the fact that the experiment filtered out germline and dbSNP variants, I was expecting a much higher mutation rate due to the fact that these individuals are highly likely to have loss of function in mismatch repair and replication repair genes.
In germline, I believe the rule of thumb is something like 1 in 1,000 bp is a variant. Meaning 1,000 mutations per Mb.
What is the rate of mutation in somatic variant calling?