What are the cons of using a whole-genome, alignment-free method such as CVTree for phylogeny?

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4.5 years ago

kristensen1234 ▴ 10

Hi all,

My question is basically as the title says: can someone help me summarize the pros and cons of using a method like CVTree for phylogeny?

I have made a tree using CVTree from 14 Metarhizium species (filamentous fungi) of approximately 40 Mbp each. It was fast and easy, but I have not had much luck searching for review of this method.

I just want to know if this is a valid method, but any insights on pros and cons (especially cons) compared to using alignment-based methods will be highly appreciated.

Cheers, Thea

genome phylogeny cvtree whole-genome • 901 views

ADD COMMENT • link 4.5 years ago by kristensen1234 ▴ 10

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Maybe this review can help:

Alignment-free sequence comparison: benefits, applications, and tools

ADD REPLY • link 4.5 years ago by h.mon 35k

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Thank you so much! I have been searching for hours, cannot believe I missed this one...

ADD REPLY • link 4.5 years ago by kristensen1234 ▴ 10

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