What is the relationship between structural variants and fusion genes?

Question

[wuqingkuangsha]

What is the relationship between structural variants and fusion genes? Is a fusion gene caused by a structural variant? For example, a deletion happens where the region between two genes is removed then two genes are fused. What about other SVs?

Answer 1

[natasha.sernova]

I think this article abstract answers your question. All fusions are structural variations, as far as I have understood, but not

visa versa. There are a lot of other kinds of structural variations, see WIKI-link at the bottom.

https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-018-1421-5

"Transcripts are frequently modified by structural variations, which lead to fused transcripts of either multiple genes,known as a fusion gene, or a gene and a previously non-transcribed sequence."

https://en.wikipedia.org/wiki/Structural_variation_in_the_human_genome