Entering edit mode
4.4 years ago
bhuwanhld18
•
0
Hi all,
I am new here. I was looking at the protein variant and i could not get any explaination for minus sign in it. Please help me to interpret.
The protein change is listed as p.(Met230Ilefs*-102).
Searched in HGVS recommendations for frameshift variants but could not find explaination for minus.
I'm not sure this is proper HGVS nomenclature. You can have situations like this:
but I haven't seen a hyphen after a frameshift in a p. before. Where did you get this annotation?
Alternatively, do you have the genomic coordinates (g.) that could be used to check the nomenclature or annotate using a variety of the online annotation services?