Question: Purines and pyrimidines in frame shift mutations
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gravatar for 3335098459
11 months ago by
333509845920
333509845920 wrote:

Hi,

I have recently identified some frameshift mutations in my gene of interest during the pan-genome study. I am curious that is there any study which mentions the occurrence of more frameshifts mutations in multiple purine sequence as compared to multiple pyrimidine sequences. For example: frameshifts will occur more in the sequence with a higher number of poly-adenine or poly-guanine homopolymers repeats as compared to poly-thymine or poly-Cytosine.

Regards

Awan

sequencing snp sequence • 213 views
ADD COMMENTlink modified 11 months ago by Cupton70 • written 11 months ago by 333509845920
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gravatar for Cupton
11 months ago by
Cupton70
Victoria, BC, Canada
Cupton70 wrote:

Sequencing errors are common in homopolymers. If I see a FS in a homopolymer, my first check is the raw sequencing data.

ADD COMMENTlink written 11 months ago by Cupton70
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