Question: Purines and pyrimidines in frame shift mutations
gravatar for 3335098459
11 months ago by
333509845920 wrote:


I have recently identified some frameshift mutations in my gene of interest during the pan-genome study. I am curious that is there any study which mentions the occurrence of more frameshifts mutations in multiple purine sequence as compared to multiple pyrimidine sequences. For example: frameshifts will occur more in the sequence with a higher number of poly-adenine or poly-guanine homopolymers repeats as compared to poly-thymine or poly-Cytosine.



sequencing snp sequence • 213 views
ADD COMMENTlink modified 11 months ago by Cupton70 • written 11 months ago by 333509845920
gravatar for Cupton
11 months ago by
Victoria, BC, Canada
Cupton70 wrote:

Sequencing errors are common in homopolymers. If I see a FS in a homopolymer, my first check is the raw sequencing data.

ADD COMMENTlink written 11 months ago by Cupton70
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 679 users visited in the last hour