This seems simple maths behind, But I always get confused with the terminology of "Fold change", "Log Fold Change" (LFC), and "Percentage of Change"., When I see some of the figure descriptions given in volcano plots, specially X axis, I get confused.
i.e. Page 64
When I google, I found this figure is easy to understand, but the figure description does not make sense for me.
for e.g. If we take two-fold change; isn't this the way we calculate LFC;
LFC = Log2 (Foldchange) = Log2(2) =>1
if X axix is in Log2 fold change, shouldn't two-fold change denotes at ± 1? Why they denote 2 fold change cutoff line in ± 2?
Below VP; Fold Change greater than 2 times and significant P value less than 0.05
See this example:
Could someone help me to understand this terminology ( "Fold change", "Log Fold Change" (LFC), and "Percentage of Change". ) easily with an example?