I’m trying to compare 4 orthologous proteins-enzymes and the corresponding pdb-files for them.
Species are rather far from each other,
so the sequences are far from identity.
Never the less their functions look close – I hope
at least their active centers have high structural identity, if it is a correct term in this case.
I would like to learn how to compare them correctly from both points of view - structure and function together. Could you please give me a good example of structure-based functional comparison? So far I failed to find any good article as an example. I hope the article will describe all the tools the authors used to accomplish the task. Thank you very much! Natalia