Nowadays, with single-cell ATAC-seq we can find subpopulations within a cell-type that has a different chromatin accessibility pattern. I was wondering if there is a way of having some glance of this kind of heterogeneity from bulk ChIP-seq or ATAC-seq. Maybe some way of clustering that, for example, lets you know that in one cell type the ChIP or ATAC signal has different components.
Imagine: I have tissue samples and I FACS sort for two cell types, cell A and cell B. I suspect cell A is actually more complex and has subtypes within. For this, it would be great to do a follow-up single cell experiment. Imagine that I cannot do that - is there a way of digging into that from the bulk ChIP or ATAC? Thank you !