The general awareness about gene regulation is that enhancer sequences from a remote location in the genome also (and quite often) interact with the gene promoter thereby triggering transcription. Several other complexes including transcription factors, co-activators, other binders play key roles too. The spatial localization of the DNA into domains, compartments, and loops bring distal regions into near proximity. The theme of transcription factories has also become known, to be discrete sites where transcripts are bred. The genome loops coordinate with the protein complexes hinged at the transcription factories as a precursor to transcription process. How can I draw a conduit between these two concepts?
Question: How are the transcription factories and the enhancer-promoter interactions linked?
16 months ago by
Shaurya Jauhari • 40
Shaurya Jauhari • 40 wrote:
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