What is configuration required for exome sequence analysis?

Question

[Karma]

I have about 40 exomes to be analyzed to call the variants. What should be the best system configuration to get these results in the fastest way

[ATpoint]

40x 144-core Skylake nodes with 1.5TB each so you can do everything in memory and everything in parallel.

Ok, now seriously: What is your budget, that is important to know first. Beyond that and normal server node would do, nothing special with exomes.

[Karma]

I have a system with following configuration

Architecture:          x86_64
CPU op-mode(s):        32-bit, 64-bit
CPU(s):                16
Thread(s) per core:    1
Core(s) per socket:    8
CPU socket(s):         2
NUMA node(s):          2
Vendor ID:             GenuineIntel
CPU family:            6
Model:                 45
Stepping:              7
CPU MHz:               2599.807
Virtualization:        VT-x
L1d cache:             32K
L1i cache:             32K
L2 cache:              256K
L3 cache:              20480K

And

10TB Harddrive
64 GB RAM

Is there any difference in using the system as GUI from server mode (only terminal)?. I have Ubuntu 18.04 Desktop as well as server mode Operating system (OS). Will using GUI based OS slowdown the process?