Entering edit mode
4.8 years ago
nazaninhoseinkhan
▴
530
Dear all,
I found no mutations or copy number alterations in about %30 of my tumor samples (stage one of tumor).
Would you please tell me if it is strange?
have anybody faced with the same issue?
Regards
Nazanin
Thank you so much for the explanation
Check out this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5720395/ - it is not about alternative mechanisms, but more about how many important mutations you may find for Different tumor types
Sure, thank u German
If an answer was helpful, you should upvote it; if the answer resolved your question, you should mark it as accepted. You can accept more than one answer if they all work.
being honest I don't like my answer - it does not go into details and is partially contradictive with well-accepted theories such as "epigenetic changes are a consequence of genomic changes" - so it is usually considered as non-driving event, that's why I wrote it as a comment in the beginning. I also feel the list is not full. I'd wish more people contribute to this question - I'd also like to read the full and well-motivated list.
E.g. here is the mutational burden per cancer type - https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0424-2/figures/2 - but this is only a part of the answer