Question: a gene become a drug target
0
gravatar for Shicheng Guo
5 weeks ago by
Shicheng Guo8.0k
Shicheng Guo8.0k wrote:

Hi All,

How to become a drug target for a gene? or the way for a gene will become a drug target? Is there any bioinformatics pipeline to generate drug target from the whole gene list?

Thanks.

target drug drug target • 119 views
ADD COMMENTlink modified 5 weeks ago by Kevin Blighe53k • written 5 weeks ago by Shicheng Guo8.0k

Maybe this is more a philosophical question. The target itself is usually a product of a gene, either a protein or its mRNA. It also need to be tractable and tractability (or druggability) can be defined in different ways. The Open Targets Platform has the batch search tool that can tell you (from a list of genes) how tractable they are, among other things. Potentially all human genome (or proteome) could be drug targets, but we know that many of the proteins are not tractable at all. Besides we need to take into account other factors such as mRNA and protein expression, protein-protein interaction, and many more...

ADD REPLYlink written 21 days ago by Denise - Open Targets5.1k
3
gravatar for Kevin Blighe
5 weeks ago by
Kevin Blighe53k
Kevin Blighe53k wrote:

Hey,

You could try Enrichr, which is also an R package.

Also look at Open Targets, which has an API.

CMAP may be another choice.

Kevin

ADD COMMENTlink written 5 weeks ago by Kevin Blighe53k
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