Since co-expression networks are build to understand the patterns of interaction/co-expression between genes, the unsigned version seems to be the best option as it disregards the sign of correlation value and can show interactions even between oppositely regulated genes. However, in case of signed-hybrid network, the negative co-relations are treated as zero. This limits the regulation between oppositely regulated genes in the network. So why is this desirable?
Question: What is the need for signed or signed hybrid (as in WGCNA) co-expression networks?
14 months ago by
Arindam Ghosh • 350
Arindam Ghosh • 350 wrote:
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