What makes certain genomes harder to sequence? Are there any trends among taxonomic groups?
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5.0 years ago
DNAlias ▴ 40

Like for example, I've heard that bird genomes are difficult to sequence because of their high degree of heterozygosity. Are there other clades known for having highly heterozygous genomes? I also know that mammalian genomes can be harder than other animals due to their large size. Are there any other trends like these?

sequencing next-gen • 756 views
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NCBI taxonomy can be potentially used to get such trends. Something like for each clade get the fraction of species with an available genome. Will try to give it a try.

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5.0 years ago
Mensur Dlakic ★ 28k

Repetitive sequences, especially long repeats, are by far the biggest challenge. Polyploidy in some plants is a problem. Sample contamination and sequencing errors contribute as well.

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