miR155HG is significantly up-regulated in EBV-transformed lymphocytes

Question

[Shicheng Guo]

How to understand miR155HG is significantly up-regulated in EBV-transformed lymphocytes?

Thanks.

Solved: EBV modulates host miR-155 expression, which is essential for the growth of EBV-infected B cells. EBV-infected cells have increased expression of miR-155 thereby disturbing the equilibrium of expression for genes regulating transcription in those cells

[cpad0112]

Did you discuss this finding with your supervisor / PI / collaborating scientist in virology esp on EBVS? Shicheng Guo

Answer 1

[ATpoint]

Did you do any literature research? https://en.wikipedia.org/wiki/MiR-155

Search for EBV, the Wiki article even mentions it in the EBV context and gives link to scientific literature.