I have methylation data (C frequency from Meth call-bismark) and Bulk RNA-seq FPKM (from RSEM) on a cell line.
I am only interested in comparing RNA-seq and methylation relations at some specific genes on this cell line. ( I do not have any other control cell line - No Foldchange, FDR, etc).
Is it logical just to compare the expression FPKM with the mean percent methylation?
For example, I am interested in genes A, B, C
Reporst that I have:
A B C Methylation: 100 80 60 Expression: 300 40 250
-> Scores for each gene:
gene A: 300/100 = 3
gene B: 40/80 = ./5
gene C: 250/60= 4.16
Will this be a right comparison/scoring?