Question: Metal Scheme STDERR vs Scheme SAMPLESIZE
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gravatar for ernst77
4 days ago by
ernst770
ernst770 wrote:

Hi,

I am running a meta analysis with metal https://genome.sph.umich.edu/wiki/METAL_Documentation and I am trying to figure out the exact differences and implications of the different analysis schemes, especially Scheme STDERR and Scheme SAMPLESIZE. The first one uses effect size estimates and standard errors, the latter one uses p-values and direction of effect, weighted according to sample-size. I am getting quite different results for both. Does anybody know when one should expect similar results for both analyses, when what should be used and what the exact differences are?

Thanks a lot!

metal metaanalysis genome • 83 views
ADD COMMENTlink modified 4 days ago by Pierre Lindenbaum125k • written 4 days ago by ernst770
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