Why two gene sequences are different beetween ensembl and ncbi?
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22 months ago
isoBA • 0

Hi, I need to get a DNA (no mRNA) sequence of that gene: https://www.ncbi.nlm.nih.gov/gene/6271 And when I download fasta, I got totaly different sequence than from ensembl: https://www.ensembl.org/Homo_sapiens/Gene/Sequence?db=core;g=ENSG00000160678;r=1:153627926-153632039

I see they has different positions of sequence, but there should include part of common region.

Can someone explain me patient why is a different and which one file will be correct whole DNA sequence for that gene? And how can I recognize that is mRNA or DNA having only a files without headers?

refseq ensembl • 475 views
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Entering edit mode
22 months ago
AsoInfo ▴ 300

Just encountered this answer form ReserchGate while looking for an answer by myself.

https://www.researchgate.net/post/Ensemble_database_vs_ncbi

In short, different transcripts will have different starting exons, so you can focus your research depending on your transcript accordingly.

Hope it helps.

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