Filter RNA-seq matrix
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22 months ago

Dear community,

I am using RNA-seq data for gene network analysis. In data pre-processing, I filter out genes with low expresion counts and genes with low coefficient of variance (CV). I found the CV on counts and logs-transformed values are quite different, which means the former is significantly larger than the later. Thus, which is better regarding CV filtering, on counts or log2-values?

Regards.

rna-seq cv • 458 views
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