looking somatic variants interpreter, AS CKB database

Question

[J.F.Jiang]

Hi,

After calling somatic variants from tumor samples against normal ones, we still get a lot of true somatic variants that require variants-drug interpretations.

CKB database offers lots of high level annotations, as well as those pre-clinic ones, which can largely provide comprehensive actionable drug-able information.

However, CKB database did not provide API service, since its commercial mode.

Is there any similar comprehensive database, since our aim is to provide/integrate API/WEB service to the workflow.

--PS Other databases listed in https://github.com/seandavi/awesome-cancer-variant-databases have been tried, but none of them perform as CKB.

Answer 1

[Kevin Blighe]

You could try Open Targets, from Denise & Co. ( https://www.opentargets.org/ / https://www.targetvalidation.org/ ).

Their related publications:

• Open Targets Platform: new developments and updates two years on

• Open Targets: a platform for therapeutic target identification and validation

Kevin