Question: Discussion on abundance of trans-eQTLs and almost no cis-eQTLs
gravatar for aritra90
13 months ago by
United States
aritra9060 wrote:


I have more of a philosophical question. I've seen papers which use skepticism in interpreting trans-eQTLs due to alignment errors or batch effects. I am doing an analysis currently with RNA-seq and genotype data, trying to find significant eQTLs.

So far I've found a lot of trans-eQTLs above the statistical significance threshold (FDR = 0.05; p = 1e-3) and zero to very minimal number of cis-eQTLs. During literature survey I found quite the opposite where people tend to find a lot of cis-eQTLs and less trans-eQTLs (which makes sense due to LD and other factors).

So my question is what caution should I exercise in interpreting this event of observing abundantly more trans-eQTLs than their cis counterparts (or is this common). Any comments/discussion on this matter would greatly help my understanding of interpreting eQTLs as winner's curse is a very common phenomenon.


ADD COMMENTlink written 13 months ago by aritra9060
Please log in to add an answer.


Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1641 users visited in the last hour