New insights from old data?
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4.6 years ago
schlogl ▴ 160

Hi there smart people!

Someone here have some links for, or papers were the author is using the 'old' data to look for new knowledge, well, let me being more clear, taking a different view from the previous author or project aims?

Thanks

Paulo

genome rna-seq sequence • 984 views
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Plenty have probably tried but it would be difficult to get a whole new publication out of meta analysis of existing data.

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Basically every computational biology paper that used published data to answer a biological question, right?

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yeah but I would like to see or read some of it

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Well, there are thousand of examples but some I can give from my field. Viruses have often been overlooked in metagenomic datasets so there are some recent papers that try to find those sequences. For example : "Giant virus diversity and host interactions through global metagenomics" "Diversity, evolution, and classification of virophages uncovered through global metagenomics" "Ocean viruses: Rigorously evaluating the metagenomic sample-to-sequence pipeline"

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Are those papers strictly using data that was generated by someone else for a different aim? Based on the example you cite I can see a discovery type study being feasible but not something comparative.

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So you need new work that seeks a different aim like a piggy-back strategy. I am not sure these fall exactly into that category. It could be in some way.

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How could I be so stupid that I did not think of this paper that I worked on.. haha Take a look at "The DNA Methylation Landscape of Giant Viruses" on biorxiv. Originally PacBio data was used to sequence the genomes but then, they discovered that they could use this same data to study the DNA methylation ! And I am sure that you will also find a lot of examples in other fields. I am curious, what do you need that for ?

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Did your group generate the original data or someone else did. If your group did then you did not need to ask for permission (as a professional courtesy) to use the data.

I think @schlogl is asking about using data that is in public space. That would likely need permission or at least notification to the original data owners. Some people may be generous about sharing without strings, others may want authorship in new work.

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It was actually our data but that was not originally generated for this purpose. If we think of public data there are plenty of papers that use them but the challenge is to find some that use in a different way that what it was meant for so my metagenomic examples are not perfect as the original purpose is still to unravel world's diversity. Tell us when you find some other examples :)

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yeah! Talking about shared data in data banks! They are free for use don't they? Then if you are clever enough to find a peace of data that was not look for the original 'owner' maybe you can freely use the data for your own purpose right?! And if you got something nice and for a huge luck your new data is good enough for a publication, well you look for the original research and ask permission or offer a collaboration for the publication. Well, that's what I am supposing that I you are 'clever' enough :)

Paulo

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