Does anyone know a genetics simulation software that can simulate regions under long-term negative-selection? Coalescent simulators such as msms are only capable of simulating selection at specific sites. We are interested in simulating negative selection over an entire region (so multiple sites simultaneously). I have a suspicion that some forward simulators are capable of doing this but I have no experience with forward simulators. If anyone thinks they know a simulator that can do what we are looking for please let me know. Thanks in advance!