Question: Sciclone cluster all around y=x
0
gravatar for April
7 months ago by
April0
April0 wrote:

I am trying to use Sciclone to do clustering on my paired diagnostic and relapsed WES data. However, all the clusters in each patient are around line y=x. But I expect to see some clusters like the cluster 4, 5 in the example figure, which was only in the diagnostic or only in the relapsed sample. How can I fix this?

example figure: Figure 3a

"Miller, Christopher A., Brian S. White, Nathan D. Dees, Malachi Griffith, John S. Welch, Obi L. Griffith, Ravi Vij et al. "SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution." PLoS computational biology 10, no. 8 (2014)."

example Figure 3a

sciclone • 224 views
ADD COMMENTlink modified 6 months ago by Chris Miller21k • written 7 months ago by April0
1
gravatar for Chris Miller
6 months ago by
Chris Miller21k
Washington University in St. Louis, MO
Chris Miller21k wrote:

This may in fact be the case - some tumors do not evolve much over time, or are largely homogeneous, in which case you would expect to see everything on the diagonal!

ADD COMMENTlink written 6 months ago by Chris Miller21k
Please log in to add an answer.

Help
Access

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.
Powered by Biostar version 2.3.0
Traffic: 1179 users visited in the last hour