Via targeted resequencing, I have identified missense mutations in my gene of interest. These missense mutations are enriched in patients versus control individuals. I made a lolliop plot to visualise where these mutations are located on the protein and to see whether they occur in protein domains. I now want to know wheter certain protein domains are enriched for these mutations, or if these mutations tend to cluster in any other region of the protein.
What is the correct way to achieve this? Are there any papers or tools that I can look into?
Thanks a lot for your suggestions.