Why some genes with negative fold change are assigned as activated upstream regulators by IPA?

Question

[Raheleh]

Hi,

I used Ingenuity Pathway Analysis (IPA) to do upstream regulator analysis for my differentially expressed genes (relapse vs. non-relapse).

I realize some of the the genes that IPA predicted them as activated upstream regulators have negative expression ration in my relapse group.

How we can explain this?

Many thanks!

[GenoMax]

Please contact IPA tech support to get an authoritative answer.