Comb-p for Differentially Methylated Regions identification

Question

[sabin]

Hi all, I would like to ask if any of you ever used the tool "comb-p" to search for differentially methylated regions. The tool wants in input a column with p-values, obtained from a statistical test, for each cpg. I was wondering whether it's correct to use the p-values obtained from the differentially methylated position analysis did with library champ (function champ.DMP).

Thank you in advance for the help!

[German.M.Demidov]

I am not familiar with neither of these packages, but I know that p values of closely located cpgs are correlated and you have to correct for autocorrelation before merging p values! :) just as described in methpipe tool paper