Question: Log2 fold change correlation for ChIP seq data - do I need a FDR cut off?
gravatar for emilyprice16
9 months ago by
emilyprice1620 wrote:

I have ChIP-seq differential binding data for two transcription factors and a histone modification. I want to see if the change in TF binding/histone modification between timepoints are correlated with each other. Therefore I am going to correlate the log2 fold change for each factor. However do I need to apply a FDR (q-value) cut-off prior to my correlation (<0.05)? My thinking is the changes in TF binding between timepoints aren't 'real' unless they are significantly different.

chip-seq • 272 views
ADD COMMENTlink written 9 months ago by emilyprice1620

Why not applying thresholds for both fold-change and FDR?

ADD REPLYlink written 9 months ago by Rashedul Islam390
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