Hi, I have Whole Exome data in the form of vcf file from 8000 normal control patients ( who do not have any skin conditions) that have identified themselves as European during the medical history. I also have vcf file from Whole Exome data from Psoriasis patients. My lab is interested in comparing the variants between the two datasets. However, I would like to perform population stratification on the control dataset to check if all the patients are European descent before I move forward in analysis. I have done some research on the tools that I can use for this purpose; however, I am still not sure how to start with vcf file. I am a novice Bioinformatician and have used PLINK for school assignments. I will really appreciate if someone can guide me on this. Thank you!
