How to replace the chromosome seq from new chromosome sequence in genome file

Question

[divya.mishra.jnu]

I want to add a new sequence in place of the old sequence in the big fasta file?

Answer 1

[colindaven]

Divide up the fasta using a script (there are various splitfasta style scripts out there in the world) then use the linux tool cat to concatenate the individual chromosomes including your new one back together.