Question: How To Assess Dendrogram Robustness
gravatar for Julien Textoris
8.1 years ago by
Marseille, France
Julien Textoris430 wrote:

Hi all,

I would like to assess the robustness of a dendrogram.

The general purpose is to compare biological samples evaluated by mass spectrometry. I developped an algorithm in order to compute a distance matrix in order to classify samples. I would like to assess the robustness of the obtained dendrogram, but i don't know really how to do so. I knew that a bioconductor package called pvclust was able to do so by bootstrapping, the problem is taht pvclust function does not accept a user-defined distance matrix computation function.

Do you know either

  • if there is another package which would allow me to define my distance definition (or distance matrix computation function)
  • if there are a good introductory course on clustering / dendrogram robustness assessment ?

Thanks in advance,


clustering • 1.9k views
ADD COMMENTlink modified 7.9 years ago by Darren J. Fitzpatrick1.1k • written 8.1 years ago by Julien Textoris430
gravatar for Darren J. Fitzpatrick
8.1 years ago by
Ireland/ United Kingdom
Darren J. Fitzpatrick1.1k wrote:

The authors of pvclust provide a method whereby you can call a custom distance function. It involves you defining your distance function in R and then setting the method.dist argument equal to your function.

ADD COMMENTlink modified 8.1 years ago • written 8.1 years ago by Darren J. Fitzpatrick1.1k

Thank you very much, that's just what i needed !


ADD REPLYlink written 8.1 years ago by Julien Textoris430
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