Question: gnoMAD mutation and essential gene
0
gravatar for dshdixit
8 months ago by
dshdixit10
dshdixit10 wrote:

When we look at specific mutation in gnoMAD how can i figure out ways to predict essential and non essential gene estimation based on given information provided?Kindly let me know.

genome • 202 views
ADD COMMENTlink written 8 months ago by dshdixit10
1

what do you mean by "essential and non essential gene estimation" ? Please rephrase your question to provide more information.

ADD REPLYlink written 8 months ago by Nicolas Rosewick9.3k

Essential i mean if the critical genes involvement can be predicted over other genes(calling non essential) in different mutation.

ADD REPLYlink written 8 months ago by dshdixit10
1

Who determines if a gene is "essential" or not? What is the context in which their being "essential" is determined?

ADD REPLYlink written 8 months ago by _r_am32k

Determination depends on how lethal the genes are, like in gnoMAD that have several genes reported in database (~20,000). If there is a way find from it?

ADD REPLYlink written 8 months ago by dshdixit10

Genes are never lethal. If expressing a gene killed the organism, evolution would select against that gene. I think you're referring to the comments you received on your previous question, where a metric measuring how tolerant a gene is to protein truncating variants is used as a measure of how "critical" the gene is to the organism's survival. Is that correct?

ADD REPLYlink written 8 months ago by _r_am32k
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