power analysis and rare variants

Question

[monaallouba]

Hello,

I need to assess how many individuals I need to sequence to find all variants with an allele frequency <0.001 with a power of 80%. How can I do that in R?

Thank you

[Ram]

• Allele Frequency among what population?
• How do you define power in this context?

[monaallouba]

allele frequency in a control population so basically, I am trying to address the following question: At what control cohort size will I have 80% statistical power (with alpha = 0.05) to detect very low frequency variants (i.e. 0.001)?

[Ram]

Is this an assignment question? Again, how do you define statistical power of variant detection?