Hello, I have a venn diagram with a list of up and down-regulated genes from experiment 1. I compared another gene list (from experiment 2) and got the overlap (108 genes are Up, 309 genes are Down and 41 genes are not deferentially expressed).
My NULL hypothesis is that the proportion of overlaps with up and down-regulated genes is 50-50 (that is random). I want to show that the proportion of down-regulated genes (as shown in the pie chart) is significant. What kind of statistical test should I do here ? Thanks.