Question: How to calculate covariance between betas for GxE interaction using PLINK 2.0

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Apprentice •

**40**wrote:Hi.

I would like to perform genome-wide meta-analysis of GxE interaction across 5 cohorts.

I'm going to use a joint meta-analysis of Mannig et al. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312394/) I know that the method needs SNP beta and SNP×E beta and covariance between the betas.

I could obtained SNP beta and the SNP×E beta from each cohort using PLINK 2.0, but I don't know how to calculate covariance using PLINK 2.0.

Could you tell me how to compute the covariance?

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modified 4 months ago
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chrchang523 ♦

**7.3k**• written 4 months ago by Apprentice •**40**