Hope someone may be able to point me in the right direction!
I've generated some polygenic risk scores for schizophrenia in a cohort of individuals with borderline intellectual disability. Trying to figure out a way to validate the scores I'm getting out of PRSice. Is there a way to do this?
My current results (with --all-score) look something like this: https://ibb.co/jv9YQP5 (sorry couldn't place the table here in an easily legible format)
There are some patterns in my results, with some individuals having identical scores at particular p-values (is this just due to the stats involved in generating the scores?), and the scores are pretty low (clustering around 0) with some changing from positive to negative depending on p-value threshold. Is this typical of polygenic risk scores?
I've followed Marees et al 2018 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001694/) and Sam Choi's tutorail (https://choishingwan.github.io/PRS-Tutorial/) to generate this, but I'm thinking I may have made errors somewhere along the line and would like to check my results somehow!
Any advice would be much appreciated!