How to export molecular action between nodes from String PPI network?
1
0
Entering edit mode
3.8 years ago
mario.red8976 ▴ 120

Hi everybody. I am using the online version of STRING (https://string-db.org) to build a PPI network using DEGs from RNAseq analysis. In the settings, I checked the "molecular action" box to visualize the predicted mode of action for the interaction between different nodes. But when I export the .tsv file from the site to load the network on cytoscape, this information is not present.

I checked all the files that can be exported and there is no trace of "molecular action". Do you know how can I export this type of info to load it into other software like cytoscape?

Or is there any other way to do this? Or other software/tools/websites? The STRING app in cytoscape do not allow to visualize the "molecular action".

Thank you for your help!

ps here's a picture of a network as an example of what I can see on STRING (with "molecular action" turned on). The different edges that you can see are what I want to export (e.g. green arrow for activation, red line for inhibition, etc).

STRING molecular action example

PPI network string systems-biology • 2.0k views
ADD COMMENT
0
Entering edit mode
3.8 years ago

This information is in the protein.actions file in the download section.

ADD COMMENT
0
Entering edit mode

Thank you for your answer! I am trying to export the network in cytoscape; is there a way to then import this information (molecular action) into the network inside cytoscape?

ADD REPLY
0
Entering edit mode

File → Import → Table from File…. and selecting appropriate options or if this doesn't work, just pre-process the file, for example replacing the gene IDs to match those you already have. To reproduce the STRING visualization, you'll also need to play with styles.

ADD REPLY

Login before adding your answer.

Traffic: 1511 users visited in the last hour
Help About
FAQ
Access RSS
API
Stats

Use of this site constitutes acceptance of our User Agreement and Privacy Policy.

Powered by the version 2.3.6