I am trying to sync up bim files from two different builds so that they have the same position and rsid for each variant
I have a bim file A from a respected group that has this line and is on hg18 coordinates
6 rs1755047 0 33478210 C G
my own bim file B on hg19 has this line, these coordinates agree with what dbsnp reports for this rsid on hg19:
6 rs1755047 0 33431319 C G
If I use UCSC liftover, the tool says
chr6:33431319 on hg19 maps to
chr6:33539297 on hg18. I would have expected
chr6:33478210 given the info in bim A.
I have 1700 of these I need to snyc up. Out of these only 80 seem to liftover properly, in the sense that lifting over bim file A from hg19 to hg18 leaves me with coordinates and rsids that match up perfectly with bim file B.
This is in the HLA region if that that makes a difference. Pretty stuck here any advice would be greatly appreciated