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2.6 years ago
yunzhe.jiang97 • 0
I am a freshman at comparative genomics. Now, I've got several sequences of genes, and I want to calculate the conservation scores of these genes. Is anyone familiar with the calculation of conservation scores? It would be nice if someone can provide a pipeline. Thanks very much.
A must read: https://www.jstor.org/stable/2461605?seq=1 (A epic Acknowledgments section). tl;dr: You have to have a phylogenetic tree. In addition, conservation of what? Of each position? of the entire gene?
Thanks for your reply. I want to calculate the conservation score of a gene.
What do you mean by calculation? Do you want to calculate conservation scores from scratch or you just want to annotate your gene list with pre-calculated conservation scores? There are multiple resources for pre-calculated conservation scores. Such as
Phylopto name a few!
Yeah. I do need to annotate my gene list with a pre-calculated conservation score.