I have a gene list of results of a new analysis and would like to test whether these are enriched in the gene lists of previous analyses. This is to serve as a kind of validation of the new method.
I saw the tool WebGestalt allows me to upload my own functional database (which would be my list of previosly identified genes) for gene set enrichment analysis or over-representation analysis.
I'm very unsure how to go about this though. Since I only test for enrichment in one or a handful of gene sets, I'm not sure if this would be appropriate? Also, would gene set enrichment analysis (with a reference set such as the genome) or over-representation analysis be more appropriate?
Any tips are greatly appreciated.