Question: Small Change In Amino Acid Sequence Leading To Distant Change In Conformation?
3
gravatar for leonardo
7.3 years ago by
leonardo40
leonardo40 wrote:

Hi all,

I'm looking for any example of a protein whose secondary or tertiary structure is significantly changed when a single or small number of mutations occur elsewhere from the affected areas. Significance here does not have to mean loss of function, but rather the protein structure is appreciably altered in some sense.

I have come across a protein of a bacterial phospholipase C that has many examples of prolines in various secondary structural contexts, but I'm looking for an example of one or a few AA changes affecting structure either downstream or globally.

I would appreciate if you could point me in the right direction.

protein • 1.2k views
ADD COMMENTlink written 7.3 years ago by leonardo40
1
gravatar for JC
7.3 years ago by
JC8.4k
Mexico
JC8.4k wrote:

Mutations in C are known to change drastically the protein conformation specially when affects disulfide bonds.

ADD COMMENTlink written 7.3 years ago by JC8.4k
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